Compounded Semaglutide

Semaglutide / Glycine / B12 can have various side effects that individuals should be aware of. Understanding these side effects and their potential treatments is crucial for anyone considering or using this medication.

Common side effects

Common side effects of Semaglutide / Glycine / B12 may include gastrointestinal issues like nausea, vomiting, diarrhea, and constipation, particularly when starting treatment. You might also experience injection site reactions, decreased appetite, and, rarely, hypoglycemia (low blood sugar) or pancreatitis (inflammation of the pancreas). To alleviate nausea, individuals can try getting fresh air, sipping cold drinks, and consuming small, frequent meals.

If these common side effects persist, it's essential to stay hydrated and seek guidance from a healthcare provider. Reactions around the injection site and headaches, other common side effects, can generally be managed with over-the-counter remedies. For severe or worsening symptoms, professional medical advice is recommended.

Uncommon and rare side effects

Uncommon side effects, affecting 1 in 100 individuals, may involve an increased pulse rate, a general feeling of being unwell, dehydration, gallbladder inflammation, and delayed stomach emptying. It’s important to speak to your healthcare provider about any concerns or adverse reactions.

Rare side effects, seen in fewer than 1 in 100 people, include kidney-related issues, such as reduced function and failure, with signs like a metallic taste, reduced urine volume, and easy bruising. Recognizing these symptoms and seeking prompt medical attention is essential.While serious side effects are rare, they may include severe allergic reactions or pancreatitis. Immediate medical attention is crucial if symptoms like difficulty breathing, swelling, or severe abdominal pain occur.

Semaglutide has demonstrated impressive effectiveness in facilitating substantial weight loss, with clinical trials showcasing its potential for individuals to achieve a significant reduction of up to 15% of their body weight within a year. These trials have highlighted semaglutide's robust impact on weight management, particularly when used alongside lifestyle modifications like dietary changes and increased physical activity.

Compounding is the process of creating a medication that’s tailored to the needs of an individual patient. For example, some patients may need a medication in liquid form when the FDA-approved drug comes in a pill. Additionally, a pharmacy can compound medications of FDA-approved drugs that are in shortage.

Compounded drugs are prepared by state-licensed compounding pharmacies that meet FDA and state requirements, including quality standards. When compounding in compliance with federal law, compounded drugs are not subject to FDA approval and do not have to undergo safety, effectiveness, or manufacturing review.

Our compounded semaglutide contains a semaglutide base, which is the same active ingredient used in some other GLP1 weight loss medication.. We never use semaglutide salts, as they have not been shown to be effective.

We exclusively work with licensed compounding pharmacies that meet rigorous FDA and state requirements for quality, and who undergo regular inspections.

Compounded semaglutide actually frees up supply of branded medications for diabetic use.  Compounding pharmacies may play a role in addressing supply shortages by preparing compounded versions of medications that are in short supply.

In the context of diabetic supply, shortages of branded diabetic medications like Ozempic can have significant implications for diabetic patients who rely on these medications to manage their condition. Guidelines and checks are in place to avoid this, however supplies of branded medications can still be under pressure.

Compounding pharmacies may help mitigate shortages of branded medications by providing compounded alternatives. This enables more people to access the benefits of semaglutide.

1. Formulation and Dosage: Wegovy and Ozempic are commercially available medications with standardized formulations and dosages. They use pre-filled pens containing the quantity a patient needs for 4 weeks. In contrast, compounded semaglutide comes in vials where the dosage is drawn from the vial using a syringe. Compounding also enables enhancements to the formula. Our treatment contains vitamin B12 and glycine to minimize side effects and optimize weight loss outcomes.
2. Regulatory Status: Wegovy and Ozempic are FDA-approved medications with established safety and efficacy profiles for their respective indications (weight management and type 2 diabetes). They have undergone extensive clinical testing and regulatory review to demonstrate their effectiveness and safety. In contrast, all compounded medications, including compounded semaglutide, are not FDA-approved.
3. Quality Control and Standardization: Commercially available medications like Wegovy and Ozempic are manufactured under strict quality control standards to ensure consistency, purity, and potency of each dose. The manufacturing processes for these medications are standardized and subject to regulatory oversight. Compounded medications may vary in quality and consistency depending on the practices of the compounding pharmacy. Compounding pharmacies are regulated, and Levity ensures an extensive quality and safety testing and monitoring process is followed with all of our compounded medication.
4. Availability and Accessibility: Wegovy and Ozempic are in short supply, which means diabetic patients (in the case of Ozempic) may struggle to get the medication they require. Weight loss patients are therefore also likely to encounter availability issues with branded formulations. Compounded semaglutide is prepared by compounding pharmacies specifically to help alleviate this shortage and ensure people who need the branded medication can still access it.

We are able to offer compounded semaglutide in 26 states. The states we supply are: Colorado, Florida, Georgia, Hawaii, Illinois, Iowa, Maine, Maryland, Massachusetts, Mississippi, Missouri, Montana, Nebraska, Nevada, New York, North Dakota, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Dakota, Tennessee, Texas, Virginia, Washington, Wyoming.

We are working to make it available in more states. If you wish to know when we might be able to supply your state, please contact us.

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